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These agents mitigate muscle atrophy by downregulating atrophy-related factors (myostatin, MuRF1, MAFbx) and upregulating myogenic transcription factors (MyoD, MyoG) via PKA/Akt/mTOR signaling

Additional information on the synthesis of the GLP-1 analogues and their characterizations is available in the Supplementary data (Supplementary Methods and Supplementary Figs

The mean absolute bioavailability following intramuscular injection was approximately 14-19% in rats and 45-51% in beagle dogs, suggesting species-specific absorption characteristics relevant for dose translation to human applications

additional contraceptive methods may be needed for 4 weeks after starting or increasing doses